Table 1. Crystal structures of Ser/Thr Protein kinases

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Group	Kinase	PDB	Organism	Ligation State	Phos. State	Activation State	Origin of Inactivity	Reference
AGC	PKA	1ATP	Mouse	MnATP and peptide	P	Active	-	^a^1
		1BKX	Mouse	Adenosine	P	Active	-	^a^2
		1CDK	Pig	PKI peptide	P	Inhibited	-	62
		1CTP	Pig	Inhibitor peptide	P	Inhibited	-	29
		1FMO	Mouse	PKI inhibitor and adenosine	P	Inhibited	-	^a^3
		1U7E	Mouse	AMPPNP, R-subunit (bovine)	P	Inhibited		27
		1J3H	Mouse	apo	P	Open	-	^a^4
		1JLU	Mouse	Substrate peptide	P	Active	-	133
		1L3R	Mouse	Transition state	P	Active	-	^a^5
	PKB	1MRV	Human	apo	U	Inactive	No helix C	33
		1MRY	Human	apo	U	Inactive	No helix C	33
		1O6K	Human	GSK3 peptide, AMPPNP	P	Active	-	31
		1O6L	Human	AMP-PNP, GSK3 peptide	P	Active	-	31
		1GZK	Human	apo	U	Inactive	DFG Out, Thr	75
		1GZN	Human	apo	U	Inactive	DFG Out, Thr	75
		1GZO	Human	apo	U	Inactive	DFG Out, Thr	^a^6
	PKC-i	1ZRZ	Human	BIN-1 inhibitor	P	Active	-	^a^7
	PDK1	1H1W	Human	ATP	P	Active	-	28
	GRK2	1YM7	Bovine	Apo	U	Active	-	29
		2BCJ	Bovine	Ga ,Gb subunits,GDP, AlF4^-	U	Active	-	80
	GRK6	2ACX	Human	AMPPNP, Mg	U	Active	-	79
	Aurora	2C6D	Human	ADPNP	U	Active	-	^a^8
		1MUO	Human	Apo	U	Inactive	DFG Out	^a^9
		1OL5	Human	TPX-2 peptide	P	Active	-	77
		2BFX	Frog	Incenp peptide	P	Active	-	78
	ROCK	2F2U	Bovine	Apo	U	Active	-	^a^10
CAMK	CamK1	1A06	Rat	Apo	U	Autoinhibited	DFG Out, Thr	37
	CamK1d	2JC6	Human	Inhibitor	U	Inactive	Act loop, autoinhibited	To be published